Winter term 2019/20

Course no.TitleDatesDurationTypeLecturer (assistant)
0000MW1828Design Priciples in Biomatter - Nature as an EngineerLink2VO
  • M. Marczynski
  • O. Lieleg
0000MW1948Experimental techniques for the characterization of biomatterLink3VO
  • C. Rickert
  • O. Lieleg
0000000406Instructions for independent scientific workLink1SE
  • O. Lieleg
000000000Journal Club: Drug DeliveryLink2SE
  • J. Boekhoven
  • O. Lieleg
0000000026Lab course biophysics for students of biochemistryLink4PR
  • A. Bausch
  • H. Dietz
  • O. Lieleg
  • M. Rief
  • F. Simmel
  • G. Woehlke
  • M. Zacharias
0000MW1833Recent Progress in BiomechanicsLink2SE
  • O. Lieleg

Microscopic Biomechanics SS

Volume: 2 SWS Lecture + 1 SWS tutorial
Credit points: 5
Lecturer: Prof. Dr. Oliver Lieleg Assistant: Benjamin Winkeljann
Content:
This lecture addresses micromechanical phenomena in bio-matter. First, the stability of chemical and physical bonds will be discussed. Then, the mechanical properties of single molecules and the application of the beam equation to biopolymers will be discussed. Further topics are the mechanism of force generation by molecular motors, e.g. for microscopic material transport or during the hearing process. The mechanical properties of biological membranes and biopolymer networks will be discussed and it will be demonstrated how nature achieves a broad spectrum of mechanical properties by fine-tuning the molecular composition of the material. Moreover, differences in the mechanical behavior of healthy and tumor cells will be highlighted and the reaction of single cells to external mechanical stimuli will be reviewed. Finally recent progress in the field of tissue engineering will be reviewed focusing on the generation of artificial cell/polymer communities.

Language: German
Place and Time: lecture: Tuesday, 9:30 – 11:00, Tutorial: Tuesday, 8:30 - 9:30, all in auditorium E.126 MSB (prev. IMETUM)
Target group: master mechanical engineering, master medical engineering, diploma mechanical engineering
Exam: oral or written

Experimental techniques for the characterization of biomaterials WS

Volume: 3 SWS lecture
Credit points: 5
Lecturer: Prof. Dr. Oliver Lieleg
Content:
This lecture discusses experimental techniques that can be used to characterize the structure and mechanics of biomaterials. First, basic imaging techniques such as optical microscopy, electron microscopy, near field and atomic force microscopy will be introduced. It will be shown how these techniques can be adjusted to increase the resolution and contrast of the obtained images so that these techniques can be used for the characterization of biological samples. In a second part, macro- and microscopic techniques for determining the viscoelastic properties of biomaterials are reviewed and the corresponding setups are discussed. In a last part, techniques for micro- and nanostructuring are introduced and it is shown how they can be applied in tandem with optical or mechanical techniques in a microfluidic setup that allows performing complex sorting or analysis steps in a “lab on a chip” device.

Language: German/English
Place and Time: Tuesday, 14 - 16:30, auditorium E.126 MSB (prev. IMETUM)
Target group: master mechanical engineering (module numerical mechanics, module medical engineering), master medical engineering, diploma mechanical engineering
Exam: oral or written

Design Principles in Biomatter – Nature as an Engineer WS

Volume: 2 SWS
Credit points: 3
Lecturer: Prof. Dr. Oliver Lieleg
Content: In this lecture, first the microstructure of biomaterials will be introduced. Using the biosynthesis of proteins, DNA-origami and virus replication as examples, self-assembly as a key principle in the design of biomaterials will be discussed. Diffusion as a key transport mechanism in bio-matter and mechanisms for its regulation will be reviewed. As one example, charge screening by counter ions will be highlighted. The microscopic design of selective permeability filters will be explained and how they are used by nature to establish and maintain gradients of e.g. ions or protons. The principles of signal transduction in neurons will be discussed – especially similarities to and differences from the charge transport in coaxial cables. Finally, the molecular principles used by nature to establish light absorption and conversion into chemical energy e.g. during photosynthesis will be discussed and key concepts of biomineralization processes will be presented.

Language: German
Place and Time: Thursday, 14:00 – 15:30, auditorium E.126 MSB (prev. IMETUM)
Target group: bachelor/master mechanical engineering, master medical engineering
Exam: written

Introduction to Bioengineering: Bio-inspired Material Design

Volume: 3 SWS
Credit points: 5 ECTS
Lecturer: Prof. Dr. Oliver Lieleg
Content:
This lecture covers phenomena that take place on the surface of materials or at the interface between two materials. For example, the following topics are discussed: surface wetting resistance (superhydrophobicity), anti-adhesive surfaces, friction and lubrication by water-based lubricants, self-lubricating materials, the generation and prevention of wear, biological glues, anti-bacterial coatings, self-assembling and self-dissolving materials. For each topic covered by this lecture, a biological model is discussed, which shows how the particular material property can be achieved. Following this introduction of biological examples, artificial, (semi-) synthetic materials are discussed whose development was inspired by biological models. Examples of technical or medical applications of such bio-inspired materials include hydrophobic building materials (mortar, cement), water collecting devices from fog, molecular coatings for increased wearing comfort of contact lenses, and synthetic cartilage replacement materials and biologically inspired band-aids and wound-glues.

Language: English
Place and Time: Thursday, 13:30 – 16:30, auditorium E.126 MSB (prev. IMETUM)
Target group: bachelor mechanical engineering
Exam: short talk and written final exam

 

Practical Training/ Block Seminar: „Experimental Characterization of Soft Materials“ SS/WS

Volume: 4 SWS
Credit points: 4
Lecturers: Prof. Dr. Oliver Lieleg Assistant: Benjamin Winkeljann
Content:
The characterization of soft materials requires methods that are quite different from those used for hard, metallic materials. Soft, biological materials are almost always viscoelastic, thus combining both elastic and viscous characteristics. At the same time, the topology of biological materials is often complex and has roughness features on different length scales. Finally, rough and smooth surfaces show a diverse tribological behavior when biological lubricants are used. This variety of complex material behavior will be examined in this practical training on the basis of 5 selected experiments. The characterization methods used here quantify the viscoelastic, tribological and topological properties of various biological materials. The following techniques are used: oscillatory rheology, rotational tribology, contact angle measurement, bright field and fluorescence microscopy, white light profilometry. The number of participants is limited to 15 persons.

Language: German/ English
Place and Time: 1 introductory day and a one-week practical course at the beginning of the semester, MSB (prev. IMETUM) lecture hall E.126 and lab E202
Target group: master mechanical engineering, master medical engineering
Exam: Evaluation of the laboratory performance consisting of 5 experiments with 1 test and 1 written analyzis

Practical training: Biophysics für Students of Biochemics WS

Umfang: 4 SWS
Credit points:

Lecurers: Prof. Dr. Matthias Rief, Prof. Dr. Oliver Lieleg, PD Dr. Günther Woehlke and colleagues of Physics-Department
Content:

The practical training offers over the term one-day experiments with a wide range of topics and methods of biophysics.

Language: German
Time and Place: Biology labs in Physics-Department and in MSB (prev. IMETUM) Wednesday 9 - 15  Disposition of the groups on the first day in Seminar room PH 3024 Chair Rief E22
Target group: Bachelor studies Biochemics
Exam: The mark is a summary of preparation, performance, finishing of the protocol and a final seminar. Immanent exam.